The active ingredient of the drug Adaptol Mebicar is close in its chemical structure to the natural metabolites of the body - its molecule consists of two methylated urea fragments that make up the bicyclic structure.
Adaptol has moderate tranquilizing (anxiolytic) activity, eliminating or weakening anxiety, anxiety, fear, internal emotional tension and irritation. The sedative effect of the drug is not accompanied by muscle relaxation and impaired coordination of movements. The drug does not reduce mental and physical activity, so Adaptol can be used during the working day or study. The drug does not cause feelings of elevated mood, a sense of euphoria. On this basis, Adaptol is referred to as daytime tranquilizers. Does not have a hypnotic effect, but enhances the effect of hypnotic drugs and improves sleep when it is disturbed.
In addition to sedative, Adaptol has a nootropic effect. The drug improves cognitive function, increases attention and mental performance, without stimulating the symptoms of productive psychopathological disorders - nonsense, pathological emotional activity.
Adaptol has antioxidant activity, therefore, acts as a membrane stabilizer, adaptogen and cerebroprotector during oxidative stress of various origins.
Adaptol acts on the activity of structures in the limbic-reticular complex, in particular on the emotiogenic zones of the hypothalamus, and also affects all 4 major neurotransmitter systems - GABA, choline, serotonin and adrenergic, contributing to their balance and integration, but does not have peripheral adrenonegative action. In the neurotransmitter profile of the drug Adaptol there is a dopamine-positive component. The drug shows antagonistic activity in relation to the excitation of adrenergic and glutamatergic systems and enhances the functioning of the inhibitory serotonin and GABAergic mechanisms of the brain. Possesses normostenicheskimi properties.
Adaptol weakens nicotine abstinence.
Pharmacokinetics. When administered orally, bioavailability is 77â€“80%; up to 40% of the drug is bound to red blood cells; the rest - 60% do not bind to blood proteins and are in the blood plasma in a free state, and therefore the drug is widely distributed in the body and penetrates through the membrane. Cmax in the blood plasma is reached in 30 minutes, a high level of concentration is maintained for 3-4 hours, then gradually decreases. The drug is completely excreted in the urine during the day, does not accumulate and is not subject to biochemical transformations in the body.
neurosis and neurosis-like states, accompanied by irritability, emotional lability, anxiety and fear; to improve the tolerability of neuroleptics or tranquilizers in order to eliminate their somatovegetative and neurological side effects caused by them; cardialgia of various origins (not associated with coronary artery disease); to facilitate the flow of somatovegetative manifestations in premenstrual syndrome and menopause.
Adaptol is shown as a cerebroprotective agent and an adaptogen with emotional and oxidative stress of various origins. In the complex therapy of nicotine addiction as a means of reducing craving for smoking.
Adaptol prescribed inside regardless of the meal. Adults take 300â€“500 mg 2â€“3 times a day. The maximum dose per dose is 3 g, the daily dose is 10 g. The duration of the course of treatment is from several days to 2-3 months. If necessary, the appointment of the drug to children aged 10 years is recommended to use Adaptol 500 mg tablets, which can be divided in half to obtain a dose of 250 mg.
For treatment with nicotine addiction, the drug is taken on 500-1000 mg 3 times a day every day for 5-6 weeks.
individual hypersensitivity to mebicar or drug components. During pregnancy and breastfeeding.
usually the drug is well tolerated.
Violations of the cardiovascular system: a decrease in blood pressure.
Disorders from the gastrointestinal tract: rarely - dyspeptic disorders. In this case, it is necessary to reduce the dose of the drug.
Respiratory system disorders: rarely - bronchospasm.
Disturbances of the skin and subcutaneous tissue: rarely - after taking in high doses, allergic reactions (rash, itching, bronchospasm) are possible. In case of an allergic reaction, the drug is discontinued.
General disorders: rarely - hypothermia, weakness. With a decrease in blood pressure and / or hypothermia (body temperature may drop by 1-1.5 Â° C), the drug should not be stopped. HELL and body temperature are normalized independently.
addiction, dependence and withdrawal syndrome with Adaptol have not been established.
Caution should be used for violations of the liver and kidneys, in patients with arterial hypotension.
Use during pregnancy and lactation. Adaptol penetrates well into all tissues and body fluids. There is insufficient data on the safety of the drug during pregnancy and lactation, therefore, the prescription of the drug for pregnant and lactating breasts is not recommended.
Children. Experience with children is absent.
The ability to influence the reaction rate when driving or working with other mechanisms. Care should be taken when driving, as sometimes the use of the drug can cause a decrease in blood pressure.
Adaptol can be combined with neuroleptics, tranquilizers (benzodiazepine), hypnotics, antidepressants and psychostimulants.
Adaptol has low toxicity. With a significant overdose, side effects may increase (allergic reactions, dyspeptic disorders, temporary decrease in blood pressure and body temperature).
Treatment: carry out conventional methods of detoxification, including gastric lavage.
at a temperature not higher than 25 Â° C. Keep out of the reach of children. Conditions of sale from pharmacies - without a prescription.